This test measures the percentage of CD3 positive alpha/beta T cells which negative for both CD4 and CD8. These cells are raised in frequency in Autoimmune Lymphoproliferative Syndrome (ALPS). ALPS is a rare disorder of lymphocyte apoptosis associated with autoimmunity and lymphoproliferation. Idiopathic thrombocytopenia purpura (ITP) and autoimmune haemolytic anaemia (AIHA) are common autoimmune phenomena in these patients.
Specimen requirements
1 mL EDTA blood must be received in the Immunology Laboratory within 48 hours of venepuncture. Samples must NOT have been refrigerated or centrifuged and must arrive before 4pm on Fridays.
Cost
Price on application
Laboratory turnaround time
3 working days
Laboratory method
FACSCanto
Reference range/units
N/A
Associated tests
Sample stability
24 hours post venepuncture (do not refrigerate or centrifuge)
Shipping and storage
Ambient temperature and first class post. Hays DX users please enquire via email below.
Samples must be received in the Immunology Laboratory within 48 hours of venepuncture. Samples must not have been refrigerated or centrifuged and must arrive before 4.00pm on Fridays.
Further information and contact details
For further information, email immunologylab.enquiries@ouh.nhs.uk
